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Charlotta Schärfe
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Charlotta Schärfe

Eberhard Karls Universität Tübingen
Fachbereich Informatik
Angewandte Bioinformatik
Raum C323, Sand 14
D-72076 Tübingen

Work: +49-7071-29-70462

Education:

  1. 2007 Abitur at Gymnasium Walsrode
  2. 2007-2010 BSc in Bioinformatics at the University of Tübingen (and two semesters at the LMU and TU Munich)
  3. 2010-2011 Msc in Biotechnology and Business Management at the University of Warwick (UK)

Biography:

Since 2011: PhD student at Applied Bioinformatics Group
09/2013 - 09/2014: Research visit at Debora Marks lab, Harvard Medical School, Boston, MA 


Theses

C. Schärfe. Humane Papillomviren und Krebs. Bachelor Thesis. Universität Tübingen. 2010
 

C. Schärfe. A Critical Assessment of the Impact of Computational Methods on the Productivity in Pharmaceutical Research and Development. Master Thesis. University of Warwick. 2011 

Publications

J.M. Nicoludis, S. Lau · C.P.I. Schärfe, D.S. Marks, W.A. Weihofen, R. Gaudet Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity. StructureOct 10. pii: S0969-2126(15)00375-5 (available online DOI: 10.1016/j.str.2015.09.005), 2015
 
M. Avbelj, O. Wolz, O. Fekonja, M. Benčina, M. Repič, J. Mavri, J. Krüger, C.Schärfe, M.D. Garcia, G. Panter, O. Kohlbacher, A.N.R. Weber, R. Jerala
Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization, Blood, 124 (26) 3896-3904 (available online: DOI: 10.1182/blood-2014-05-573188), 2014
 
Y. Gofman, C. Schärfe, D.S. Marks, T. Haliloglu, N. Ben-Tal Structure, Dynamics and Implied Gating Mechanism of a Human Cyclic Nucleotide-Gated Channel, PLoS Comput Biol 10(12): e1003976 (available online: DOI:10.1371/journal.pcbi.1003976), 2014
 
T.A. Hopf*, C.P.I. Schärfe*,  J.P.G.L.M. Rodrigues*, A.G. Green, O. Kohlbacher, C. Sander, A.M.J.J. Bonvin, D.S. Marks Sequence co-evolution gives 3D contacts and structures of protein complexes. eLife Sep 25;3. (available online DOI: 10.7554/eLife.03430), 2014
 
R. Grunzke, S. Breuers, S. Gesing, S. Herres-Pawlis, M. Kruse, D. Blunk , L. de la Garza, L. Packschies , P. Schäfer, C. Schärfe, T. Schlemmer , T. Steinke, B. Schuller , R. Müller-Pfefferkorn, R. Jäkel , W. Nagel , M. Atkinson and J. Krüger: Standards-based metadata management for molecular simulations, Concurrency and Computation: Practice and Experience, (available online DOI: 10.1002/cpe.3116), 2013.
 
L. de la Garza, J. Krüger, C. Schärfe, M. Röttig, S. Aiche, K. Reinert and O. Kohlbacher  From the desktop to the grid: conversion of KNIME Workflows to gUSE, Proc. of 5th Workshop IWSG 2013, June 3-5 2013, Zurich, Switzerland, CEUR Workshop Proceedings, ISSN 1613-0073, 2013. 
 
L. Packschies,G.  Birkenheuer, D. Blunk, S.  Breuers, A.  Brinkmann, L. de la Garza, I. dos Santos Vieira, G. Fels, S. Gesing, R. Grunzke, S. Herres-Pawlis, O. Kohlbacher, J. Krüger, M. Kruse, U. Lang, R. Müller-Pfefferkorn, P. Schäfer, T. Schlemmer, C. Schärfe, T. Steinke, K.-D. Warzecha, A. Zink. The MoSGrid – E-Science Gateway: Molecular Simulations in a Distributed Computing Environment. 8th German Conference on Chemoinformatics. Goslar. Nov. 2012
 

Talks

C. Schärfe, J. Taeger, P. Reuter, N. Fischer, J. Krüger, B. Wissinger, O. Kohlbacher. Development of a Pharmacophore Model for Pharmacological Chaperones Targeting Mutant Trafficking-Deficient CNG Channels. 8th German Conference on Chemoinformatics. Goslar. Nov. 2012
 
T.A. Hopf*, C.P.I. Schärfe*,  J.P.G.L.M. Rodrigues*, A.G. Green, O. Kohlbacher, C. Sander, A.M.J.J. Bonvin, D.S. Marks Sequence co-evolution gives 3D contacts and structures of protein complexes, Highlights ISMB 2015