Applied Bioinformatics Group


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Welcome to the Kohlbacher lab!


Group Photo

The group of Oliver Kohlbacher was established in 2003 and is primarily working on computer-aided drug design, immunoinformatics, structural bioinformatics as well as bioinformatics applications in proteomics, metabolomics and systems biology. The group collaborates closely with a large number of experimental groups to gain access to up-to-date and relevant datasets.

Besides classical structural bioinformatics methods, we are focused on the use of combinatorial optimization, graph theoretic approaches and machine learning. To make the methods we develop accessible to a larger audience, we contribute to several larger open-source software projects, e.g., BALL (structural bioinformatics), OpenMS (proteomics) and BN++/BiNA (network analysis).

Most recent publications:

Gifford, CA, Ziller, MJ, Gu, H, Trapnell, C, Donaghey, J, Tsankov, A, Shalek, AK, Shishkin, AA, Issner, R, Zhang, X, Fostel, JL, Holmes, L, Meldrim, J, Guttman, M, Epstein, C, Park, H, Kohlbacher, O, Rinn, J, Gnirke, A, Lander, ES, Bernstein, BE, and Meissner, A (2013). Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells. Cell, 153.

Novák, J, Sachsenberg, T, Hoksza, D, Skopal, T, and Kohlbacher, O (2013). A Statistical Comparison of SimTandem with State-of-the-Art Peptide Identification Tools. In: 7th International Conference on Practical Applications of Computational Biology & Bioinformatics, pp. 101–109, Springer.

Recent news:

Sandra Gesing received her PhD: We are pleased to congratulate Dr. Sandra Gesing on passing her PhD exam and wish her all the best for the future.

6th OpenMS User Meeting – High-­performance software for high-­throughput proteomics and metabolomics: We are happy to announce the 6th OpenMS User Meeting on September 3th – 5th at the ETH Zürich.